Human NKIRAS2 Recombinant Protein (RPPB4100)
- SKU:
- RPPB4100
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NYR9
Frequently bought together:
Description
| Product Name: | Human NKIRAS2 Recombinant Protein |
| Product Code: | RPPB4100 |
| Size: | 10µg |
| Species: | Human |
| Target: | NKIRAS2 |
| Synonyms: | NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2, NKIRAS2, KBRAS2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NKIRAS2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRSLLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG |
NFKB inhibitor interacting Ras-like 2 (NKIRAS2) is an inhibitor of the transcription factor NF-kappaB. NKIRAS2 is similar to the Ras-like small GTPases which associate with IkappaB. NKIRAS2 is an atypical Ras-like protein which functions as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more impervious to degradation.
NKIRAS2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids (1-191 a.a) and having a molecular mass of 24kDa.NKIRAS2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NKIRAS2: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric, Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 17q21.2 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NYR9 |
| NCBI GenInfo Identifier: | 74734716 |
| NCBI Gene ID: | 28511 |
| NCBI Accession: | Q9NYR9.1 |
| UniProt Secondary Accession: | Q9NYR9,Q6PK52, Q96KC7, Q9NSX1, A6NCZ5, B3KNN0, B4DNM3 |
| UniProt Related Accession: | Q9NYR9 |
| Molecular Weight: | 10,770 Da |
| NCBI Full Name: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| NCBI Synonym Full Names: | NFKB inhibitor interacting Ras like 2 |
| NCBI Official Symbol: | NKIRAS2�� |
| NCBI Official Synonym Symbols: | KBRAS2; kappaB-Ras2�� |
| NCBI Protein Information: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| UniProt Protein Name: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| UniProt Synonym Protein Names: | I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 |
| Protein Family: | NF-kappa-B inhibitor-interacting Ras-like protein |
| UniProt Gene Name: | NKIRAS2�� |
| UniProt Entry Name: | KBRS2_HUMAN |
