Human PTGES3 Recombinant Protein (RPPB2221)
- SKU:
- RPPB2221
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15185
- Research Area:
- Enzymes
Description
| Product Name: | Human PTGES3 Recombinant Protein |
| Product Code: | RPPB2221 |
| Size: | 20µg |
| Species: | Human |
| Target: | PTGES3 |
| Synonyms: | TEBP, CPGES, SID3177, 5730442A20Rik, p23, HSP90 co-chaperone, Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, Telomerase-binding protein p23, Progesterone receptor complex p23, PTGES3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The PTGES3 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT & 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE |
PTGES3 takes part as a cochaperone and is involved in signal transduction. PTGES3 is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexess. PTGES3 is necessary for appropriate functioning of the glucocorticoid and other steroid receptors.PTGES3 localizes to genomic response elements in a hormone-dependent method and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.
Recombinant Human PTGES3 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 160 amino acids (1-160 a.a.) and having a molecular mass of 18.6 kDa.PTGES3 is purified by convential chromatogrpahy techniques.
| UniProt Protein Function: | TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family. |
| UniProt Protein Details: | Protein type:Transferase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3; Isomerase Chromosomal Location of Human Ortholog: 12q13.3|12 Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleoplasm; nucleus; telomerase holoenzyme complex Molecular Function:prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; RNA-dependent DNA replication; signal transduction; telomere maintenance |
| NCBI Summary: | This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q15185 |
| NCBI GenInfo Identifier: | 8928247 |
| NCBI Gene ID: | 10728 |
| NCBI Accession: | Q15185.1 |
| UniProt Secondary Accession: | Q15185,Q8WU70, A8K7D0, B4DHP2, B4DP11, B4DP21, |
| UniProt Related Accession: | Q15185 |
| Molecular Weight: | 16,476 Da |
| NCBI Full Name: | Prostaglandin E synthase 3 |
| NCBI Synonym Full Names: | prostaglandin E synthase 3 |
| NCBI Official Symbol: | PTGES3�� |
| NCBI Official Synonym Symbols: | P23; TEBP; cPGES�� |
| NCBI Protein Information: | prostaglandin E synthase 3 |
| UniProt Protein Name: | Prostaglandin E synthase 3 |
| UniProt Synonym Protein Names: | Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 |
| UniProt Gene Name: | PTGES3�� |
| UniProt Entry Name: | TEBP_HUMAN |
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