Description
| Product Name: | Human RAB3IL1 Recombinant Protein |
| Product Code: | RPPB4366 |
| Size: | 10µg |
| Species: | Human |
| Target: | RAB3IL1 |
| Synonyms: | GRAB, Rab-3A-interacting-like protein 1, Guaninenucleotide exchange factor for Rab-3A, Rab3A-interacting-like protein 1, Rabin3-like1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RAB3IL1 protein solution (0.25mg/ml) containing Phosphatebuffer saline (pH 7.4) and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMWSGPPQ PDQGLPPPLA AVPVPWKSTD PCQGHRESPG ALVETSAGEEAQGQEGPAAA QLDVLRLRSS SMEIREKGSE FLKEELHRAQ KELKLKDEEC ERLSKVREQL EQELEELTAS LFEEAHKMVREANMKQAASE KQLKEARGKI DMLQAEVTAL KTLVITSTPA SPNRELHPQL LSPTKAGPRK GHSRHKSTSSTLCPAVCPAA GHTLTPDREG KEVDTILFAE FQAWRESPTL DKTCPFLERV YREDVGPCLD FTMQELSVLVRAAVEDNTLT IEPVASQTLP TVKVAEVDCS STNTCALSGL TRTCRHRIRL GDSKSHYYIS PSSRARITAVCNFFTYIRYI QQGLVRQDAE PMFWEIMRLR KEMSLAKLGF FPQEA |
RAB3A Interacting Protein Like 1 (RAB3IL1) is a 382 amino acid protein which is a member of the SEC2 family. RAB3IL1 is a guanine nucleotide exchange factor (GEF) for Rab3A. RAB3IL1 competes for interaction with Rab3A and IHPK1 via its coiled coil domain, which doesn�t involve IHPK1 kinase activity.
RAB3IL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 405 amino acids (1-382a.a) and having a molecular mass of 45kDa.RAB3IL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB3IL1: Guanine nucleotide exchange factor (GEF) for Rab3A, a GTPase that regulates synaptic vesicle exocytosis. Belongs to the SEC2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rab; GEFsChromosomal Location of Human Ortholog: 11q12.2Molecular Function: protein binding; Rab guanyl-nucleotide exchange factor activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q8TBN0 |
| NCBI GenInfo Identifier: | 74730489 |
| NCBI Gene ID: | 5866 |
| NCBI Accession: | Q8TBN0.1 |
| UniProt Secondary Accession: | Q8TBN0,Q86V32, Q9P1Q8 |
| UniProt Related Accession: | Q8TBN0 |
| Molecular Weight: | 39,791 Da |
| NCBI Full Name: | Guanine nucleotide exchange factor for Rab-3A |
| NCBI Synonym Full Names: | RAB3A interacting protein like 1 |
| NCBI Official Symbol: | RAB3IL1�� |
| NCBI Official Synonym Symbols: | GRAB�� |
| NCBI Protein Information: | guanine nucleotide exchange factor for Rab-3A |
| UniProt Protein Name: | Guanine nucleotide exchange factor for Rab-3A |
| UniProt Synonym Protein Names: | Rab-3A-interacting-like protein 1; Rab3A-interacting-like protein 1; Rabin3-like 1 |
| Protein Family: | Guanine nucleotide exchange factor |
| UniProt Gene Name: | RAB3IL1�� |
| UniProt Entry Name: | R3GEF_HUMAN |
