Description
| Product Name: | Human RPL7A Recombinant Protein |
| Product Code: | RPPB4489 |
| Size: | 10µg |
| Species: | Human |
| Target: | RPL7A |
| Synonyms: | 60S ribosomal protein L7a, L7A, SURF3, TRUP, PLA-Xpolypeptide, Surfeit locus protein 3, SURF-3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RPL7A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSMPKGKKAKGKKVAPAPA VVKKQEAKKV VNPLFEKRPK NFGIGQDIQP KRDLTRFVKW PRYIRLQRQR AILYKRLKVPPAINQFTQAL DRQTATQLLK LAHKYRPETK QEKKQRLLAR AEKKAAGKGD VPTKRPPVLR AGVNTVTTLVENKKAQLVVI AHDVDPIELV VFLPALCRKM GVPYCIIKGK ARLGRLVHRK TCTTVAFTQV NSEDKGALAKLVEAIRTNYN DRYDEIRRHW GGNVLGPKSV ARIAKLEKAK AKELATKLG |
Ribosomal Protein L7A (RPL7A) is a ribosomal protein which is a component of the 60S subunit. RPL7A protein is a member of the L7AE family of ribosomal proteins. RPL7A interacts with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and hinder their ability to transactivate by inhibiting their binding to their DNA response elements.
RPL7A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 289 amino acids (1-266 a.a) and having a molecular mass of 32.4kDa.RPL7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPL7A: Belongs to the ribosomal protein L7Ae family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Translation; Ribosomal Chromosomal Location of Human Ortholog: 9q34 Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleus; polysomal ribosome Molecular Function:protein binding; RNA binding Biological Process: maturation of LSU-rRNA; mRNA catabolic process, nonsense-mediated decay; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translational initiation; viral transcription |
| NCBI Summary: | Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62424 |
| NCBI GenInfo Identifier: | 54039239 |
| NCBI Gene ID: | 6130 |
| NCBI Accession: | P62424.2 |
| UniProt Secondary Accession: | P62424,P11518, Q5T8U4, |
| UniProt Related Accession: | P62424 |
| Molecular Weight: | 29,996 Da |
| NCBI Full Name: | 60S ribosomal protein L7a |
| NCBI Synonym Full Names: | ribosomal protein L7a |
| NCBI Official Symbol: | RPL7A�� |
| NCBI Official Synonym Symbols: | L7A; TRUP; SURF3�� |
| NCBI Protein Information: | 60S ribosomal protein L7a |
| UniProt Protein Name: | 60S ribosomal protein L7a |
| UniProt Synonym Protein Names: | PLA-X polypeptide; Surfeit locus protein 3 |
| Protein Family: | 60S ribosomal protein |
| UniProt Gene Name: | RPL7A�� |
| UniProt Entry Name: | RL7A_HUMAN |
