Human RRM2 Recombinant Protein (RPPB2260)
- SKU:
- RPPB2260
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31350
- Research Area:
- Enzymes
Description
| Product Name: | Human RRM2 Recombinant Protein |
| Product Code: | RPPB2260 |
| Size: | 25µg |
| Species: | Human |
| Target: | RRM2 |
| Synonyms: | EC 1.17.4.1, RR2M, RR2, Ribonucleotide Reductase M2, R2, RRM2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The RRM2 protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 0.1M NaCl, & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF |
RRM2 catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis RRM2 is regulated in a cell-cycle dependent method. RRM2 supplies the precursors essential for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 Inhibits Wnt signaling.
RRM2 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 409 amino acids (1-389 a.a.) and having a molecular mass of 47 kDa. The RRM2 is fused to a 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RRM2: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 1.17.4.1; Oxidoreductase Chromosomal Location of Human Ortholog: 2p25-p24 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding; metal ion binding; ribonucleoside-diphosphate reductase activity Biological Process: G1/S-specific transcription in mitotic cell cycle; deoxyribonucleoside diphosphate metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; deoxyribonucleotide biosynthetic process; protein heterotetramerization; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle |
| NCBI Summary: | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P31350 |
| NCBI GenInfo Identifier: | 400979 |
| NCBI Gene ID: | 6241 |
| NCBI Accession: | P31350.1 |
| UniProt Secondary Accession: | P31350,Q5WRU7, B2R9B5, J3KP43, |
| UniProt Related Accession: | P31350 |
| Molecular Weight: | 389 |
| NCBI Full Name: | Ribonucleoside-diphosphate reductase subunit M2 |
| NCBI Synonym Full Names: | ribonucleotide reductase M2 |
| NCBI Official Symbol: | RRM2�� |
| NCBI Official Synonym Symbols: | R2; RR2; RR2M�� |
| NCBI Protein Information: | ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; ribonucleotide reductase M2 polypeptide |
| UniProt Protein Name: | Ribonucleoside-diphosphate reductase subunit M2 |
| UniProt Synonym Protein Names: | Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit |
| Protein Family: | Ribonucleoside-diphosphate reductase |
| UniProt Gene Name: | RRM2�� |
| UniProt Entry Name: | RIR2_HUMAN |
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