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Human sIL 2R Recombinant Protein (RPPB0486)

SKU:
RPPB0486
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01589
Research Area:
Cytokines
€273
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Description

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Product Name:Human sIL 2R Recombinant Protein
Product Code:RPPB0486
Size:10µg
Species:Human
Target:sIL 2R
Synonyms:CD25, IL2R, TCGFR, IL-2RA, sIL-2RA, TAC antigen, sIL-2R, IDDM10, p55.
Source:Escherichia Coli
Physical Appearance:Sterile colorless liquid formulation.
Formulation:IL-2R His-Tag protein is supplied in 1x PBS and 50% glycerol pH 7.4.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

IL2-Ra is one of the three constituent subunits of the IL2 receptor. IL-2Ra is released into the serum after increased cellular expression such as increased activation of B and T cells. Clinical manifestations of IL2-Ra elevation include autoimmune conditions and some leukemias and lymphomas.

Interleukin-2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (22-213) corresponding to the mature IL2-R protein with an amino terminal hexahistidine tag.The IL-2R is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: plasma membrane

Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction

Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of

NCBI Summary:The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
UniProt Code:P01589
NCBI GenInfo Identifier:124317
NCBI Gene ID:3559
NCBI Accession:P01589.1
UniProt Secondary Accession:P01589,Q5W007,
UniProt Related Accession:P01589
Molecular Weight:30,819 Da
NCBI Full Name:Interleukin-2 receptor subunit alpha
NCBI Synonym Full Names:interleukin 2 receptor subunit alpha
NCBI Official Symbol:IL2RA��
NCBI Official Synonym Symbols:p55; CD25; IL2R; IMD41; TCGFR; IDDM10��
NCBI Protein Information:interleukin-2 receptor subunit alpha
UniProt Protein Name:Interleukin-2 receptor subunit alpha
UniProt Synonym Protein Names:TAC antigen; p55; CD_antigen: CD25
UniProt Gene Name:IL2RA��

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