Human TARBP2 Recombinant Protein (RPPB4906)
- SKU:
- RPPB4906
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15633
Description
| Product Name: | Human TARBP2 Recombinant Protein |
| Product Code: | RPPB4906 |
| Size: | 20µg |
| Species: | Human |
| Target: | TARBP2 |
| Synonyms: | LOQS, TRBP, TRBP1, TRBP2, RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TARBP2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MLAANPGKTP ISLLQEYGTR IGKTPVYDLL KAEGQAHQPN FTFRVTVGDT SCTGQGPSKK AAKHKAAEVA LKHLKGGSML EPALEDSSSF SPLDSSLPED IPVFTAAAAA TPVPSVVLTR SPPMELQPPV SPQQSECNPV GALQELVVQK GWRLPEYTVT QESGPAHRKE FTMTCRVERF IEIGSGTSKK LAKRNAAAKM LLRVHTVPLD ARDGNEVEPD DDHFSIGVGS RLDGLRNRGP GCTWDSLRNS VGEKILSLRS CSLGSLGALG PACCRVLSEL SEEQAFHVSY LDIEELSLSG LCQCLVELST QPATVCHGSA TTREAARGEA ARRALQYLKI MAGSK |
TAR RNA Binding Protein 2 (TARBP2) is a component of the RISC loading complex which takes part in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. TARBP2, which is also known as the micro-RNA (miRNA) loading complex (miRLC), contains three DRBM (double-stranded RNA-binding) domains. TARBP2 binds to the HIV-1 TAR RNA and stimulates translation of TAR-containing RNAs.
TARBP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 345 amino acids (1-345 a.a) and having a molecular mass of 36.9kDa. TARBP2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC). |
| UniProt Protein Details: | Protein type:Translation; Motility/polarity/chemotaxis; RNA processing; RNA-binding Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding; siRNA binding; protein homodimerization activity; miRNA binding; double-stranded RNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA |
| NCBI Summary: | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15633 |
| NCBI GenInfo Identifier: | 209572714 |
| NCBI Gene ID: | 6895 |
| NCBI Accession: | Q15633.3 |
| UniProt Related Accession: | Q15633 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | RISC-loading complex subunit TARBP2 |
| NCBI Synonym Full Names: | TARBP2 subunit of RISC loading complex |
| NCBI Official Symbol: | TARBP2�� |
| NCBI Official Synonym Symbols: | LOQS; TRBP; TRBP1; TRBP2�� |
| NCBI Protein Information: | RISC-loading complex subunit TARBP2 |
| UniProt Protein Name: | RISC-loading complex subunit TARBP2 |
| UniProt Synonym Protein Names: | TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein |
| UniProt Gene Name: | TARBP2�� |
| UniProt Entry Name: | TRBP2_HUMAN |
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