Human TNNI2 Recombinant Protein (RPPB4978)
- SKU:
- RPPB4978
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P48788
Description
| Product Name: | Human TNNI2 Recombinant Protein |
| Product Code: | RPPB4978 |
| Size: | 10µg |
| Species: | Human |
| Target: | TNNI2 |
| Synonyms: | Troponin I fast skeletal muscle, Troponin I fast-twitch isoform, TNNI2, DA2B, FSSV, fsTnI, AMCD2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colourless liquid formualtion. |
| Formulation: | The protein solution contains 20mM Tris-HCl, 500mM NaCl and 10mM b-ME, pH 7.5. |
| Stability: | TNNI2 Human although stable at 10°C for 7 days, should be stored below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
TNNI2 is a fast-twitch skeletal muscle protein, belongs to the troponin I gene family, and is part of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, together with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. Other than muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a coactivator of estrogen receptor-related receptor alpha. Furthermore, TNNI2 suppresses tumor growth in human ovarian carcinoma. Mutations in the TNNI2 gene cause myopathy and distal arthrogryposis type 2B.
Skeletal isoforms of Troponin I were suggested to be used as markers of acute and chronic skeletal muscle injuries. In skeletal muscles Troponin I is presented by two forms, slow (21.6 kDa) and fast (21.2 kDa) skeletal. The protein (Fast Skeletal Troponin I) migrates on SDS-PAGE to approximately 26.5kDa.
| UniProt Protein Function: | TNNI2: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin I family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: troponin complex; cytosol; nucleus Molecular Function:troponin T binding; protein binding; actin binding Biological Process: skeletal muscle contraction; regulation of muscle contraction; positive regulation of transcription, DNA-dependent; muscle filament sliding Disease: Arthrogryposis, Distal, Type 2b |
| NCBI Summary: | This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P48788 |
| NCBI GenInfo Identifier: | 1351297 |
| NCBI Gene ID: | 7136 |
| NCBI Accession: | P48788.2 |
| UniProt Secondary Accession: | P48788,A6NIV8, A6NJU5, |
| UniProt Related Accession: | P48788 |
| Molecular Weight: | 182 |
| NCBI Full Name: | Troponin I, fast skeletal muscle |
| NCBI Synonym Full Names: | troponin I type 2 (skeletal, fast) |
| NCBI Official Symbol: | TNNI2�� |
| NCBI Official Synonym Symbols: | DA2B; FSSV; fsTnI; AMCD2B�� |
| NCBI Protein Information: | troponin I, fast skeletal muscle; troponin I fast twitch 2; troponin I, skeletal, fast; troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform |
| UniProt Protein Name: | Troponin I, fast skeletal muscle |
| UniProt Synonym Protein Names: | Troponin I, fast-twitch isoform |
| Protein Family: | Troponin |
| UniProt Gene Name: | TNNI2�� |
| UniProt Entry Name: | TNNI2_HUMAN |
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