Human WWOX Recombinant Protein (RPPB2418)
- SKU:
- RPPB2418
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NZC7
- Research Area:
- Enzymes
Description
| Product Name: | Human WWOX Recombinant Protein |
| Product Code: | RPPB2418 |
| Size: | 10µg |
| Species: | Human |
| Target: | WWOX |
| Synonyms: | FOR, WOX1, FRA16D, HHCMA56, PRO0128, SDR41C1, D16S432E, WWOX, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The WWOX solution (1mg/ml) contains 20mM Tris pH-8, & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by�SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG |
WWOX is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and involved in the regulation of a broad range of cellular functions such as protein degradation, transcription, and RNA splicing. WWOX functions synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX takes part in tumor necrosis factor (TNF)-mediated cell death. Loss of WWOX expression is associated with pancreatobiliary cancers. Reduced expression levels of WWOX protein is associated with the pathogenesis of basal-like differentiation in breast cancer. Loss of WWOX expression is associated with extrahepatic cholangiocarcinoma. WWOX gene alteration is an early genetic alteration contributes to oral carcinogenesis. WWOX induces apoptosis and inhibits human hepatocellular carcinoma cell growth through a mechanism enhanced by JNK inhibition.
WWOX Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 254 amino acids (1-234 a.a.) and having a molecular mass of 28.3 kDa.The WWOX is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WWOX: an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Oxidoreductase; Apoptosis; EC 1.1.1.- Chromosomal Location of Human Ortholog: 16q23 Cellular Component: cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleus; plasma membrane Molecular Function:coenzyme binding; cofactor binding; enzyme binding; oxidoreductase activity; protein binding; protein dimerization activity Biological Process: negative regulation of Wnt receptor signaling pathway; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; steroid metabolic process; Wnt receptor signaling pathway Disease: Epileptic Encephalopathy, Early Infantile, 28 |
| NCBI Summary: | This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9NZC7 |
| NCBI GenInfo Identifier: | 74725363 |
| NCBI Gene ID: | 51741 |
| NCBI Accession: | Q9NZC7.1 |
| UniProt Secondary Accession: | Q9NZC7,Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4 Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5, A8K323, |
| UniProt Related Accession: | Q9NZC7 |
| Molecular Weight: | 23,868 Da |
| NCBI Full Name: | WW domain-containing oxidoreductase |
| NCBI Synonym Full Names: | WW domain containing oxidoreductase |
| NCBI Official Symbol: | WWOX�� |
| NCBI Official Synonym Symbols: | FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E�� |
| NCBI Protein Information: | WW domain-containing oxidoreductase |
| UniProt Protein Name: | WW domain-containing oxidoreductase |
| UniProt Synonym Protein Names: | Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1 |
| Protein Family: | WW domain-containing oxidoreductase |
| UniProt Gene Name: | WWOX�� |
| UniProt Entry Name: | WWOX_HUMAN |
