Description
| Product Name: | Human YEATS4 Recombinant Protein |
| Product Code: | RPPB5171 |
| Size: | 10µg |
| Species: | Human |
| Target: | YEATS4 |
| Synonyms: | YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41, YAF9, 4930573H17Rik, B230215M10Rik. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | YEATS4 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 2mM DTT,0.2M NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMFKRMAE FGPDSGGRVK GVTIVKPIVY GNVARYFGKK REEDGHTHQW TVYVKPYRNE DMSAYVKKIQ FKLHESYGNP LRVVTKPPYE ITETGWGEFE IIIKIFFIDP NERPVTLYHL LKLFQSDTNA MLGKKTVVSE FYDEMIFQDP TAMMQQLLTT SRQLTLGAYK HETEFAELEV KTREKLEAAK KKTSFEIAEL KERLKASRET INCLKNEIRK LEEDDQAKDI |
YEATS Domain Containing 4 (YEATS4) has a high sequence homology to the human MLLT1, and yeast and human MLLT3 proteins. MLLT1 and MLLT3 proteins, both belong to a group of transcription factors, which indicates that YEATS might also represent a transcription factor. YEATS is believed to be necessary for RNA transcription. The YEATS gene has been shown to be amplified in tumors.
YEATS4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-227 a.a.) and having a molecular mass of 28.9kDa. YEATS4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 12q13-q15 Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus Molecular Function:protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O95619 |
| NCBI GenInfo Identifier: | 59799075 |
| NCBI Gene ID: | 8089 |
| NCBI Accession: | O95619.1 |
| UniProt Secondary Accession: | O95619,Q9NQD0, |
| UniProt Related Accession: | O95619 |
| Molecular Weight: | 227 |
| NCBI Full Name: | YEATS domain-containing protein 4 |
| NCBI Synonym Full Names: | YEATS domain containing 4 |
| NCBI Official Symbol: | YEATS4�� |
| NCBI Official Synonym Symbols: | YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik�� |
| NCBI Protein Information: | YEATS domain-containing protein 4; nuBI1; NuMA binding protein 1; nuMA-binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41 |
| UniProt Protein Name: | YEATS domain-containing protein 4 |
| UniProt Synonym Protein Names: | Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1 |
| Protein Family: | YEATS domain-containing protein |
| UniProt Gene Name: | YEATS4�� |
| UniProt Entry Name: | YETS4_HUMAN |
