The IL18RAP Polyclonal Antibody (PAC043242) is a valuable tool for researchers studying IL18RAP, a receptor protein involved in the interleukin-18 signaling pathway. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting.IL18RAP, also known as IL-18R accessory protein, plays a crucial role in the regulation of immune responses and inflammation.
By binding to IL18RAP, researchers can study the downstream effects of interleukin-18 signaling, providing insights into the mechanisms of inflammatory and immune-related diseases. This antibody is essential for studies in immunology, inflammation, and autoimmune disorders, offering a deeper understanding of IL18RAP function and its potential as a therapeutic target.
Antibody Name:
IL18RAP Antibody (PACO43242)
Antibody SKU:
PACO43242
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Interleukin-18 receptor accessory protein (390-599AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43242 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human epityphlon tissue using PACO43242 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43242 at dilution of 1:100.
Background:
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.
IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.Protein type: Cell surface; Membrane protein, integralChromosomal Location of Human Ortholog: 2q12Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: cell surface receptor linked signal transduction; immune response; inflammatory response
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
