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Integrin alpha 6 (ITGA6/CD49f) Rabbit Monoclonal Antibody (CAB19070)

SKU:
CAB19070
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Integrin alpha 6 (ITGA6/CD49f) Rabbit Monoclonal Antibody
SKU:CAB19070
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 481-591 of human Integrin alpha 6 (ITGA6/CD49f) (NP_001073286.1).
Sequence:IDLR QKTA CGAP SGIC LQVK SCFE YTAN PAGY NPSI SIVG TLEA EKER RKSG LSSR VQFR NQGS EPKY TQEL TLKR QKQK VCME ETLW LQDN IRDK LRPI PITA SVEI QEP
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:JEB6; CD49f; VLA-6; ITGA6A; ITGA6B; Integrin alpha 6 (ITGA6/CD49f)
Positive Sample:U-251MG,SW480,mouse lung,rat lung,rat kidney
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:106kDa/119kDa/121kDa/122kDa/124kDa/126kDa
Observed MW:125kDa

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3655
Clone Number:ARC51523
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of A-431 cells, using Integrin alpha 6 (ITGA6/CD49f) (ITGA6/CD49f) antibody (CAB19070) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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