The Integrin alpha 6 Rabbit Monoclonal Antibody (CAB19070) is a high-quality antibody designed for research involving integrin alpha 6, a cell surface receptor involved in cell adhesion and migration. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.Integrin alpha 6 is known to play a critical role in various physiological processes, including cell proliferation, differentiation, and tumor progression. By targeting this protein, researchers can gain valuable insights into the mechanisms underlying these processes, making it a valuable tool for studies in cell biology and cancer research.
With its ability to specifically bind to integrin alpha 6, this antibody enables precise detection and analysis of the protein in different cell types and tissues. Its versatility and reliability make it an ideal choice for investigating the functional role of integrin alpha 6 in various biological contexts, paving the way for new discoveries and advancements in the field.
Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:
106kDa/119kDa/121kDa/122kDa/124kDa/126kDa
Observed MW:
125kDa
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3655
Clone Number:
ARC51523
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of A-431 cells, using Integrin alpha 6 (ITGA6/CD49f) (ITGA6/CD49f) antibody (CAB19070) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
