Description
MARK1/MARK2/MARK3/MARK4 Antibody (PACO01041)
The MARK1/MARK2/MARK3/MARK4 Antibody (PACO01041) is a highly specific and sensitive tool for research involving the MARK family of proteins. These proteins play key roles in regulating cellular processes such as cell division, cell migration, and cell polarity. The antibody is produced in rabbits and has been validated for use in various applications, including Western blot and immunofluorescence.The MARK family of proteins are crucial for maintaining cellular integrity and function, making them important targets for study in a wide range of research areas including cell biology, neurobiology, and cancer research.
By using the MARK1/MARK2/MARK3/MARK4 Antibody, researchers can accurately detect and analyze the expression and localization of these proteins in different cell types and tissues, allowing for a better understanding of their roles and potential therapeutic implications.
| Antibody Name: | MARK1/MARK2/MARK3/MARK4 Antibody |
| Antibody SKU: | PACO01041 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human MARK1/2/3/4. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin |
| UniProt Protein Function: | MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway |
| UniProt Code: | Q9P0L2 |
| NCBI GenInfo Identifier: | 124056494 |
| NCBI Gene ID: | 4139 |
| NCBI Accession: | Q9P0L2.2 |
| UniProt Secondary Accession: | Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1, |
| UniProt Related Accession: | Q9P0L2 |
| Molecular Weight: | 84,911 Da |
| NCBI Full Name: | Serine/threonine-protein kinase MARK1 |
| NCBI Synonym Full Names: | microtubule affinity regulating kinase 1 |
| NCBI Official Symbol: | MARK1Â Â |
| NCBI Official Synonym Symbols: | MARK; Par1c; Par-1c  |
| NCBI Protein Information: | serine/threonine-protein kinase MARK1 |
| UniProt Protein Name: | Serine/threonine-protein kinase MARK1 |
| UniProt Synonym Protein Names: | MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | MARK1Â Â |
| UniProt Entry Name: | MARK1_HUMAN |
