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APC Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0486)

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SKU AGEL0486
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Mouse
Isotype IgG2a,k
Clone PK136
Conjugation APC
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Description

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APC Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161/NK1.1 Monoclonal Antibody (APC-conjugated, PK136) is a valuable tool for researchers studying natural killer (NK) cells and their associated cell surface markers. This antibody, specifically targeting the CD161/NK1.1 protein, is a monoclonal antibody derived from hybridoma technology, ensuring high specificity and sensitivity in experimental applications.CD161, also known as NK1.1, is a marker commonly used to identify NK cells in mice. These cells play a critical role in the immune response, particularly in recognizing and eliminating virally infected cells and tumor cells. By targeting CD161/NK1.

1, researchers can accurately identify and analyze NK cell populations in various tissues and experimental models.The APC conjugation of the PK136 antibody allows for easy detection using flow cytometry, providing researchers with a powerful tool to investigate NK cell biology in various immune-related studies. Whether studying immune responses, infectious diseases, or cancer immunology, the Mouse CD161/NK1.1 Monoclonal Antibody (APC-conjugated, PK136) offers precise and reliable detection of NK cells, supporting detailed analysis and characterization in diverse research settings.

Product Title:APC Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0486
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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