Mouse IL 28B Recombinant Protein (RPPB0653)
- SKU:
- RPPB0653
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q8CGK6
- Research Area:
- Cytokines
Frequently bought together:
Description
| Product Name: | Mouse IL 28B Recombinant Protein |
| Product Code: | RPPB0653 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | IL 28B |
| Synonyms: | Interferon lambda-3, IFN-lambda-3, Interleukin-28B, IL-28B, Ifnl3, Il28, Il28b. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IL28B protein was lyophilized from a 0.2�m filtered concentrated solution in 1xPBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IL-28B in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized�IL-28B although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL28B should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | DPVPRATRLP VEAKDCHIAQ FKSLSPKELQ AFKKAKGAIE KRLLEKDMRC SSHLISRAWD LKQLQVQERP KALQAEVALT LKVWENINDS ALTTILGQPL HTLSHIHSQL QTCTQLQATA EPKPPSRRLS RWLHRLQEAQ SKETPGCLED SVTSNLFQLL LRDLKCVASG DQCV |
| Biological Activity: | The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 30 ng/ml, corresponding to a specific activity of > 3.3 � 104 IU/mg. |
IL-28B is a cytokine remotely related to type I interferons and the IL-10 family. Interleukin-28B, interleukin 28A (IL28A), and interleukin 29 (IL29) are 3 closely related cytokine genes which form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by these 3 genes can be induced by viral infection. All 3 cytokines interact with a heterodimeric class II cytokine receptor which consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
IL-28B Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 174 amino acids and having a molecular mass of 19.6kDa.The IL28B is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.Protein type: Secreted; Secreted, signal peptideCellular Component: extracellular space; extracellular regionMolecular Function: cytokine activity; receptor bindingBiological Process: positive regulation of immune response; innate immune response; JAK-STAT cascade; defense response to virus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8CGK6 |
| NCBI GenInfo Identifier: | 28893579 |
| NCBI Gene ID: | 338374 |
| NCBI Accession: | NP_796370.1 |
| UniProt Secondary Accession: | Q8CGK6,Q4VK73 |
| UniProt Related Accession: | Q8CGK6 |
| Molecular Weight: | 21,664 Da |
| NCBI Full Name: | interferon lambda-3 |
| NCBI Synonym Full Names: | interferon lambda 3 |
| NCBI Official Symbol: | Ifnl3�� |
| NCBI Official Synonym Symbols: | Il28; IFL-1; Il28b; IL-28B; INF-alpha; INF-lambda�� |
| NCBI Protein Information: | interferon lambda-3; IFN-lambda-3; interleukin 28; interleukin 28B; interleukin-28B; interferon alpha |
| UniProt Protein Name: | Interferon lambda-3 |
| UniProt Synonym Protein Names: | Interleukin-28B |
| Protein Family: | Interferon |
| UniProt Gene Name: | Ifnl3�� |
| UniProt Entry Name: | IFNL3_MOUSE |
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