The PD-L2 (CD273) Monoclonal Antibody is a research tool specifically designed for studying the programmed death ligand 2 (PD-L2) protein, a key player in immune regulation and tolerance. This monoclonal antibody, produced using hybridoma technology, exhibits high specificity and sensitivity for detecting PD-L2 in various biological samples.PD-L2, also known as CD273, is an immune checkpoint molecule that interacts with its receptor PD-1 to suppress immune responses, playing a critical role in immune evasion and immune tolerance in the context of cancer and autoimmune diseases. The PD-L2 Monoclonal Antibody enables researchers to detect and analyze PD-L2 expression in cells and tissues, providing valuable insights into its function in immunology and cancer biology.
By understanding the role of PD-L2 in immune regulation and its impact on the tumor microenvironment, researchers can develop targeted therapies that modulate the PD-1/PD-L1/PD-L2 axis to enhance anti-tumor immune responses and potentially improve clinical outcomes in cancer patients. Additionally, studying PD-L2 expression and function may lead to the identification of novel therapeutic targets and biomarkers for predicting response to immunotherapy treatments.
Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis.
Purification Method:
Affinity purification
Gene ID:
80380
Clone Number:
ARC60190
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PD-L2/CD273 Rabbit mAb (CAB23287) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
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