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PE Anti-Human CD49d Antibody [HP1/2] (AGEL3481)

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SKU AGEL3481
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG2a, k
Clone HP1/2
Conjugation PE
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Description

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PE Anti-Human CD49d Antibody [HP1/2]

The Anti-Human CD49d Antibody (HP1/2) from Assaygenie is a premium product designed for research applications involving the CD49d protein, an integrin subunit known to play a crucial role in cell adhesion and migration processes. This antibody, specifically developed for human samples, is produced using high-quality materials and validated for use in a variety of experimental techniques.CD49d, also referred to as integrin alpha-4, is a key molecule involved in cell-cell and cell-matrix interactions, making it essential for processes like immune cell trafficking and tissue development. The Anti-Human CD49d Antibody (HP1/2) binds specifically to the CD49d protein, allowing for accurate detection and analysis in different cell types and experimental conditions.

Its reactivity and specificity make it an excellent tool for researchers studying cell adhesion, migration, and related pathways.By targeting CD49d, researchers can gain valuable insights into cell behavior, immune responses, and disease processes, particularly in contexts such as inflammation, cancer metastasis, and autoimmune disorders. The precise detection and manipulation of CD49d using the Anti-Human CD49d Antibody (HP1/2) can facilitate the development of novel therapies and interventions aimed at modulating cell adhesion and migration mechanisms for therapeutic purposes.

Product Title:PE Anti-Human CD49d Antibody [HP1/2]
SKU:AGEL3481
Size:20 Tests, 100 Tests, 200 Tests
Clone No:HP1/2
Synonyms:VLA-4 α chain; α4 integrin; Integrin α4 chain; ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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