The PP2A-A (PR65/PPP2R1B) Polyclonal Antibody (CAB21559) is a valuable tool for researchers studying the PP2A-A (PR65/PPP2R1B) protein, a key regulatory subunit of the PP2A complex involved in various cellular processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.The PP2A-A (PR65/PPP2R1B) protein is known to play a crucial role in regulating cell growth, differentiation, and apoptosis, making it a target of interest in cancer research and other related fields. By detecting and analyzing the PP2A-A (PR65/PPP2R1B) protein in different cell types, this antibody enables researchers to further unravel the cellular pathways influenced by PP2A-A (PR65/PPP2R1B) and its implications in disease development.
Understanding the function and regulation of PP2A-A (PR65/PPP2R1B) is essential for developing potential therapeutic strategies targeting this protein in diseases such as cancer, neurodegenerative disorders, and metabolic conditions. The PP2A-A (PR65/PPP2R1B) Polyclonal Antibody (CAB21559) is a reliable tool for unraveling the complexities of PP2A-A (PR65/PPP2R1B) and its role in cellular physiology.
Product Name:
PP2A-Aβ/PR65β/PPP2R1B Polyclonal Antibody
SKU:
CAB21559
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 468-667 of human PP2A-Aβ/PR65β/PPP2R1B (NP_859050.1).
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
5519
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type(WT) and PP2A-Aβ/PR65β/PPP2R1B knockout (KO) hek293T(KO) cells, using PP2A-Aβ/PR65β/PPP2R1B antibody (CAB21559) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
