The PTPRT Polyclonal Antibody (PAC018858) is a valuable tool for researchers studying the protein tyrosine phosphatase receptor T (PTPRT), a key player in cell signaling and regulation. This antibody, produced in rabbits, demonstrates high specificity and reactivity towards human samples, making it an excellent choice for Western blot applications. By targeting the PTPRT protein, this antibody enables precise detection and analysis of PTPRT expression in a variety of cell types, offering researchers insights into its role in various biological processes.PTPRT, belonging to the protein tyrosine phosphatase family, is involved in regulating cellular functions such as growth, differentiation, and apoptosis.
Dysregulation of PTPRT has been linked to several diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target. Research into PTPRT-mediated signaling pathways can provide valuable information for the development of targeted therapies and diagnostic tools for these conditions.Overall, the PTPRT Polyclonal Antibody is a reliable tool for investigating the function and significance of PTPRT in biological processes and disease states, offering researchers the opportunity to contribute to advancements in the fields of cancer biology, neurobiology, and personalized medicine.
Antibody Name:
PTPRT Antibody (PACO18858)
Antibody SKU:
PACO18858
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human PTPRT
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18858(PTPRT Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Synonyms:
Protein tyrosine phosphatase, receptor type, T
UniProt Protein Function:
RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]