Description
Anti-SLC13A2 Antibody (CAB8473)
The SLC13A2 Polyclonal Antibody (CAB8473) is a vital tool for researchers studying SLC13A2, a sodium-dependent citrate transporter involved in cellular metabolism and ion transport. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to the SLC13A2 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential asset for studies in the fields of biochemistry and cell biology.
SLC13A2 plays a crucial role in regulating citrate levels within cells, impacting processes such as fatty acid synthesis and energy production. Dysregulation of SLC13A2 has been linked to metabolic disorders, making it a promising target for research into conditions like obesity, diabetes, and metabolic syndrome. Understanding the function and regulation of SLC13A2 is key to developing potential therapeutic interventions that target cellular metabolism and ion transport pathways.
| Antibody Name: | Anti-SLC13A2 Antibody |
| Antibody SKU: | CAB8473 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-455 of human SLC13A2 (NP_003975.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, U-937, MCF7, Mouse kidney, Mouse liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-455 of human SLC13A2 (NP_003975.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TREP GFFL GWGN LAFP NAKG ESMV SDGT VAIF IGII MFII PSKF PGLT QDPE NPGK LKAP LGLL DWKT VNQK MPWN IVLL LGGG YALA KGSE RSGL SEWL GNKL TPLQ SVP |
| Gene ID: | 9058 |
| Uniprot: | Q13183 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 64kDa/69kDa |
| Observed MW: | 80kDa |
| Synonyms: | SLC13A2, NADC1, NaCT, NaDC-1, SDCT1 |
| Background: | The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of cyclophilin b. The encoded protein may play a role in the formation of kidney stones. |
| UniProt Protein Function: | SLC13A2: Cotransport of sodium ions and dicarboxylates such as succinate and citrate. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:low affinity sodium:dicarboxylate symporter activity Biological Process: dicarboxylic acid transport; transport; sodium ion transport; transmembrane transport |
| UniProt Code: | Q13183 |
| NCBI GenInfo Identifier: | 225637549 |
| NCBI Gene ID: | 9058 |
| NCBI Accession: | NP_001139447.1 |
| UniProt Secondary Accession: | Q13183,Q4VAR7, B2RBI9, B4DPL1, E7ETH5, |
| UniProt Related Accession: | Q13183 |
| Molecular Weight: | 64,410 Da |
| NCBI Full Name: | solute carrier family 13 member 2 isoform a |
| NCBI Synonym Full Names: | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 |
| NCBI Official Symbol: | SLC13A2Â Â |
| NCBI Official Synonym Symbols: | NaCT; NADC1; SDCT1; NaDC-1Â Â |
| NCBI Protein Information: | solute carrier family 13 member 2; Na(+)-coupled citrate transporter; Na(+)/dicarboxylate cotransporter 1; renal sodium/dicarboxylate cotransporter |
| UniProt Protein Name: | Solute carrier family 13 member 2 |
| UniProt Synonym Protein Names: | Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC13A2Â Â |
| UniProt Entry Name: | S13A2_HUMAN |
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