The TNFRSF9 Polyclonal Antibody (CAB2025) is a valuable tool for researchers studying TNFRSF9, a cell surface receptor involved in regulating immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications.TNFRSF9, also known as CD137 or 4-1BB, plays a crucial role in modulating T cell activation and immune responses. Its involvement in enhancing T cell proliferation and cytokine production makes it a key target for research in immunology and cancer studies. By binding specifically to the TNFRSF9 protein, this antibody allows for precise detection and analysis in various cell types, providing valuable insights into the role of TNFRSF9 in immune regulation.
Understanding the function of TNFRSF9 is essential for developing targeted therapies for cancer, autoimmune diseases, and other immune-related disorders. By investigating the signaling pathways and interactions involving TNFRSF9, researchers can gain valuable information to advance the development of novel treatments and improve patient outcomes. The TNFRSF9 Polyclonal Antibody (CAB2025) offers a reliable tool for studying TNFRSF9 and its implications in immune system regulation and disease pathogenesis.
Product Name:
4-1BB/CD137 Rabbit Polyclonal Antibody
SKU:
CAB2025
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human 4-1BB/CD137 (NP_001552.2).
Sequence:
SMCE QDCK QGQE LTKK GCKD CCFG TFND QKRG ICRP WTNC SLDG KSVL VNGT KERD VVCG PSPA DLSP GASS VTPP APAR EPGH SPQI ISFF LALT STAL L
Tested Applications:
WBIHC-PELISA
Recommended Dilution:
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:
ILA; 4-1BB; CD137; CDw137; IMD109; 4-1BB/CD137
Positive Sample:
Mouse spleen,Rat spleen
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein.
Calculated MW:
28kDa
Observed MW:
27kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Purification Method:
Affinity purification
Gene ID:
3604
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using 4-1BB/CD137 Rabbit pAb (CAB2025) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
