Anti-4-1BB/CD137 Antibody (CAB2025)
- SKU:
- CAB2025
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-4-1BB/CD137 Antibody |
| Antibody SKU: | CAB2025 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human 4-1BB/CD137 (NP_001552.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human 4-1BB/CD137 (NP_001552.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GTKE RDVV CGPS PADL SPGA SSVT PPAP AREP GHSP QIIS FFLA LTST ALLF LLFF LTLR FSVV KRGR KKLL YIFK QPFM RPVQ TTQE EDGC SCRF PEEE E |
| Gene ID: | 3604 |
| Uniprot: | Q07011 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 27kDa |
| Observed MW: | 27kDa |
| Synonyms: | TNFRSF9, 4-1BB, CD137, CDw137, ILA |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. |
| UniProt Protein Function: | TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36 Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane Molecular Function:cytokine binding; receptor activity Biological Process: negative regulation of cell proliferation; apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q07011 |
| NCBI GenInfo Identifier: | 728738 |
| NCBI Gene ID: | 3604 |
| NCBI Accession: | Q07011.1 |
| UniProt Related Accession: | Q07011,AAB34924 |
| Molecular Weight: | 27,899 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 9 |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 9 |
| NCBI Official Symbol: | TNFRSF9Â Â |
| NCBI Official Synonym Symbols: | ILA; 4-1BB; CD137; CDw137Â Â |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 9 |
| UniProt Synonym Protein Names: | 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137 |
| UniProt Gene Name: | TNFRSF9Â Â |
| UniProt Entry Name: | TNR9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using 4-1BB/CD137 antibody (CAB2025) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded Mouse spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens). |
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