![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/1280x1280/products/214408/569507/anti-mouse-ctla-4-9d9-in-vivo-antibody-ultra-low-endotoxin__11900.1770912807.jpg?c=2?imbypass=on "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin")
Description
Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin
Introducing the Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a specialized monoclonal antibody tailored for in vivo research. This antibody specifically targets the CTLA-4 protein, a critical regulator in immune checkpoint pathways, making it indispensable for studies in immunology, particularly those investigating immune response modulation and autoimmunity. With a rat IgG2b kappa isotype, this antibody ensures exceptional purity and ultra-low endotoxin levels (<0.001 EU/µg), making it ideal for sensitive applications such as ELISA, flow cytometry, functional assays, and in vivo experiments. Available in multiple sizes, it is formulated in a phosphate-buffered saline solution to maintain its stability and efficacy under experimental conditions.
Enhance the precision and reliability of your immunological research with the Anti-Mouse CTLA-4 [9D9] In Vivo Antibody from Assay Genie. CTLA-4 (Cytotoxic T-Lymphocyte-associated Protein 4) is a protein receptor that downregulates immune responses. CTLA-4 is predominantly expressed on the surface of T cells and plays a pivotal role in managing immune homeostasis and preventing autoimmune reactions. By targeting CTLA-4, researchers can explore novel therapeutic avenues in cancer immunotherapy and autoimmune disease management.
| Product Name: | Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin |
| Product Code: | IVMB0073 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | 9D9 |
| Protein: | CTLA-4 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56 |
| Isotype: | Mouse IgG2b |
| Reactivity: | Mouse |
| Immunogen: | Not Available |
| Applications: | FA, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | FA, WB |
| Reactivity: | Mouse |
| Host Species: | Mouse |
| Specificity: | Clone 9D9 recognizes an epitope on mouse CTLA-4. |
| Antigen Distribution: | CTLA-4 is expressed on activated T and B lymphocytes. |
| Immunogen: | Not Available |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | <0.5 EU/mg as determined by the LAL method |
| Purity: | ≥98% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
| Technical Datasheet: | View |
| Protein: | CTLA-4 |
| Function: | Negative regulator of T cell activation |
| Ligand/Receptor: | CD80 (B7.1), CD86 (B7.2) |
| Research Area: | Immunology, Inhibitory Molecules |
| Mouse IgG2b Isotype Control | |
|---|---|
| Clone | MPC-11 |
| Isotype | Mouse IgG2b |
| Endotoxin Level | Ultra Low Endotoxin |
![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/608x608/products/214408/569507/anti-mouse-ctla-4-9d9-in-vivo-antibody-ultra-low-endotoxin__11900.1770912807.jpg?c=2 "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin")
![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/214407/569387/anti-mouse-ctla-4-9d9-in-vivo-antibody-low-endotoxin__60403.1770909495.jpg?c=2 "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin")
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![Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/214382/569436/anti-mouse-ctla-4-9h10-in-vivo-antibody-low-endotoxin__38829.1770909942.jpg?c=2 "Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin")
