Human PRMT3 Recombinant Protein (RPPB2186)
- SKU:
- RPPB2186
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60678
- Research Area:
- Enzymes
Description
| Product Name: | Human PRMT3 Recombinant Protein |
| Product Code: | RPPB2186 |
| Size: | 20µg |
| Species: | Human |
| Target: | PRMT3 |
| Synonyms: | Protein Arginine Methyltransferase 3, Heterogeneous Nuclear Ribonucleoprotein, Methyltransferase-Like Protein 3, HRMT1L3, HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae), Protein Arginine N-Methyltransferase 3, HMT1 HnRNP Methyltransferase-Like 3, EC 2.1.1.- ,EC 2.1.1, PRMT3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PRMT3 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4) and 20% glycerol, 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMCSLASG ATGGRGAVEN EEDLPELSDS GDEAAWEDED DADLPHGKQQ TPCLFCNRLF TSAEETFSHC KSEHQFNIDS MVHKHGLEFY GYIKLINFIR LKNPTVEYMN SIYNPVPWEK EEYLKPVLED DLLLQFDVED LYEPVSVPFS YPNGLSENTS VVEKLKHMEA RALSAEAALA RAREDLQKMK QFAQDFVMHT DVRTCSSSTS VIADLQEDED GVYFSSYGHY GIHEEMLKDK IRTESYRDFI YQNPHIFKDK VVLDVGCGTG ILSMFAAKAG AKKVLGVDQS EILYQAMDII RLNKLEDTIT LIKGKIEEVH LPVEKVDVII SEWMGYFLLF ESMLDSVLYA KNKYLAKGGS VYPDICTISL VAVSDVNKHA DRIAFWDDVY GFKMSCMKKA VIPEAVVEVL DPKTLISEPC GIKHIDCHTT SISDLEFSSD FTLKITRTSM CTAIAGYFDI YFEKNCHNRV VFSTGPQSTK THWKQTVFLL EKPFSVKAGE ALKGKVTVHK NKKDPRSLTV TLTLNNSTQT YGLQ |
PRMT3, also known as protein arginine N-methyltransferase 3, is a memberof the protein arginine methyltransferase family. PRMT3 catalyzes themethylation of guanidino nitrogens of arginyl residues of proteins.� PRMT3 operates on 40S ribosomal protein S2 ,rpS2,which is the major in-vivo substrate, additionally PRMT3 �is also involved in the proper maturation ofthe 80S ribosome.
PRMT3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 554 amino acids (1-531 a.a) and having a molecular mass of 62.3kDa.PRMT3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PRMT3: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Belongs to the protein arginine N-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; EC 2.1.1.-; Methyltransferase; Methyltransferase, protein arginine Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: cytosol Molecular Function:histone-arginine N-methyltransferase activity; methyltransferase activity; protein binding; protein-arginine omega-N asymmetric methyltransferase activity Biological Process: negative regulation of protein ubiquitination; regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | O60678 |
| NCBI GenInfo Identifier: | 44771198 |
| NCBI Gene ID: | 10196 |
| NCBI Accession: | NP_005779.1 |
| UniProt Related Accession: | O60678 |
| Molecular Weight: | 52kDa; 59kDa |
| NCBI Full Name: | protein arginine N-methyltransferase 3 isoform 1 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 3 |
| NCBI Official Symbol: | PRMT3�� |
| NCBI Official Synonym Symbols: | HRMT1L3�� |
| NCBI Protein Information: | protein arginine N-methyltransferase 3 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 3 |
| UniProt Synonym Protein Names: | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 |
| Protein Family: | Protein arginine N-methyltransferase |
| UniProt Gene Name: | PRMT3�� |
| UniProt Entry Name: | ANM3_HUMAN |
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