Human PTPMT1 Recombinant Protein (RPPB2227)
- SKU:
- RPPB2227
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WUK0
- Research Area:
- Enzymes
Description
| Product Name: | Human PTPMT1 Recombinant Protein |
| Product Code: | RPPB2227 |
| Size: | 20µg |
| Species: | Human |
| Target: | PTPMT1 |
| Synonyms: | Protein-tyrosine phosphatase mitochondrial 1, PTEN-like phosphatase, Phosphoinositide lipid phosphatase, PTPMT1, MOSP, PLIP, DUSP23, PNAS-129. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PTPMT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMKVPGR AHRDWYHRID PTVLLGALPL RSLTRQLVQD ENVRGVITMN EEYETRFLCN SSQEWKRLGV EQLRLSTVDM TGIPTLDNLQ KGVQFALKYQ SLGQCVYVHC KAGRSRSATM VAAYLIQVHK WSPEEAVRAI AKIRSYIHIR PGQLDVLKEF HKQITARATK DGTFVISKT |
Protein tyrosine phosphatase mitochondrial 1 (PTPMT1) is a broadly expressed PTP membrane protein with high expression levels in pancreatic beta cells. The PTPMT1 protein is completely restricted to the matrix face of the inner membrane of the mitochondrion. PTPMT1 is responsible for dephosphorylating mitochondrial proteins and thus has a major role in the production of ATP. PTPMT1 exhibits a specific preference for the lipid signaling molecule phosphatidylinositol 5-phosphate as substrate.
PTPMT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (28-201) and having a molecular mass of 22.6kDa.PTPMT1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PTPMT1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; EC 3.1.3.27; EC 3.1.3.48; Mitochondrial; Phosphatase, lipid; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: mitochondrion; nucleus Molecular Function:phosphatidylglycerophosphatase activity; phosphoinositide 5-phosphatase activity; protein binding Biological Process: cardiolipin biosynthetic process |
| UniProt Code: | Q8WUK0 |
| NCBI GenInfo Identifier: | 221218988 |
| NCBI Gene ID: | 114971 |
| NCBI Accession: | NP_001137456.1 |
| UniProt Secondary Accession: | Q8WUK0,Q7Z557, Q96CR2, Q9BXV8, E9PAT8, |
| UniProt Related Accession: | Q8WUK0 |
| Molecular Weight: | 35.9kD |
| NCBI Full Name: | phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, mitochondrial 1 |
| NCBI Official Symbol: | PTPMT1�� |
| NCBI Official Synonym Symbols: | MOSP; PLIP; DUSP23; PNAS-129�� |
| NCBI Protein Information: | phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| UniProt Protein Name: | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| UniProt Synonym Protein Names: | PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48) |
| Protein Family: | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase |
| UniProt Gene Name: | PTPMT1�� |
