Human QPCT Recombinant Protein (RPPB2237)
- SKU:
- RPPB2237
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16769
- Research Area:
- Enzymes
Description
| Product Name: | Human QPCT Recombinant Protein |
| Product Code: | RPPB2237 |
| Size: | 10µg |
| Species: | Human |
| Target: | QPCT |
| Synonyms: | Glutaminyl-Peptide Cyclotransferase, Glutaminyl Cyclase, QC,Glutaminyl-TRNA Cyclotransferase, GlutamylCyclase, EC 2.3.2.5, SQC, EC, GCT, Glutaminyl-peptide cyclotransferase. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | QPCT protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | VSPSASAWPE EKNYHQPAIL NSSALRQIAE GTSISEMWQN DLQPLLIERYPGSPGSYAAR QHIMQRIQRL QADWVLEIDT FLSQTPYGYR SFSNIISTLN PTAKRHLVLA CHYDSKYFSHWNNRVFVGAT DSAVPCAMML ELARALDKKL LSLKTVSDSK PDLSLQLIFF DGEEAFLHWSPQDSLYGSRH LAAKMASTPH PPGARGTSQL HGMDLLVLLD LIGAPNPTFPNFFPNSARWF ERLQAIEHEL HELGLLKDHS LEGRYFQNYS YGGVIQDDHI PFLRRGVPVL HLIPSPFPEVWHTMDDNEEN LDESTIDNLN KILQVFVLEY LHLHHHHHH |
Glutaminyl-Peptide Cyclotransferase, also known as QPCT is a member ofthe glutaminyl-peptide cyclotransferase family. QPCT is responsible for thebiosynthesis of pyroglutamyl peptides. Furthermore, QPCT is partial againstacidic and tryptophan residues adjacent to the N-terminal glutaminyl residueand a lack of importance of chain length following the second residue. QPCTcatalyzes N-terminal pyroglutamate formation, also in vitro, it catalyzespyroglutamate formation of N-terminally truncated form of APP amyloid-betapeptides [Glu-3]-beta-amyloid.
QPCT produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 339 amino acids (29-361a.a.) and having a molecular mass of 38.7kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). QPCT is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | QPCT: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.2.5; Transferase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p22.2 Molecular Function:glutaminyl-peptide cyclotransferase activity; zinc ion binding Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; protein modification process |
| NCBI Summary: | This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16769 |
| NCBI GenInfo Identifier: | 2498824 |
| NCBI Gene ID: | 25797 |
| NCBI Accession: | Q16769.1 |
| UniProt Secondary Accession: | Q16769,Q16770, Q3KRG6, Q53TR4, |
| UniProt Related Accession: | Q16769 |
| Molecular Weight: | 361 |
| NCBI Full Name: | Glutaminyl-peptide cyclotransferase |
| NCBI Synonym Full Names: | glutaminyl-peptide cyclotransferase |
| NCBI Official Symbol: | QPCT�� |
| NCBI Official Synonym Symbols: | QC; GCT; sQC�� |
| NCBI Protein Information: | glutaminyl-peptide cyclotransferase; EC; glutamyl cyclase; glutaminyl cyclase; glutaminyl-tRNA cyclotransferase |
| UniProt Protein Name: | Glutaminyl-peptide cyclotransferase |
| UniProt Synonym Protein Names: | Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC |
| UniProt Gene Name: | QPCT�� |
| UniProt Entry Name: | QPCT_HUMAN |
