Human RELT Recombinant Protein (RPPB0926)
- SKU:
- RPPB0926
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q969Z4
- Research Area:
- Cytokines
Description
| Product Name: | Human RELT Recombinant Protein |
| Product Code: | RPPB0926 |
| Size: | 10µg |
| Species: | Human |
| Target: | RELT |
| Synonyms: | RELT, TNF Receptor, Receptor Expressed In Lymphoid Tissues, Tumor Necrosis Factor Receptor Superfamily Member 19L, RELT Tumor Necrosis Factor Receptor, TNFRSF19L, Tumor Necrosis Factor Receptor Superfamily, Member 19-Like, TRLT. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | RELT protein solution (0.5mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | STTLWQCPPG EEPDLDPGQG TLCRPCPPGT FSAAWGSSPC QPHARCSLWR RLEAQVGMATRDTLCGDCWP GWFGPWGVPR VPCQPCSWAPLGTHGCDEWG RRARRGVEVA AGASSGGETR�QPGNGTRAGG PEETAAQVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP�EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK�EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI�AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH |
RELTis expressed in hematopoietic tissues and peripheral blood leukocytesand is a part of thetumor necrosis factor receptor superfamily. RELT mediates activation of NF-kappa-B and takes part in T-cell activation.overexpression of RELT in HEK-293 cells induces p38 and JNK signalling and leads to apoptosis.�it can also costimulate T-cell proliferation in the presence of CD3 signalling.
RELT produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 376 amino acids (26-162a.a.) and having a molecular mass of 41.4kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).RELT is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RELT: Mediates activation of NF-kappa-B. May play a role in T- cell activation. Belongs to the RELT family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: integral to plasma membrane Molecular Function:tumor necrosis factor receptor activity Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q969Z4 |
| NCBI GenInfo Identifier: | 21264092 |
| NCBI Gene ID: | 84957 |
| NCBI Accession: | Q969Z4.1 |
| UniProt Secondary Accession: | Q969Z4,Q86V34, Q96JU1, Q9BUX7, |
| UniProt Related Accession: | Q969Z4 |
| Molecular Weight: | 46,092 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 19L |
| NCBI Synonym Full Names: | RELT tumor necrosis factor receptor |
| NCBI Official Symbol: | RELT�� |
| NCBI Official Synonym Symbols: | TRLT; TNFRSF19L�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 19L |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 19L |
| UniProt Synonym Protein Names: | Receptor expressed in lymphoid tissues |
| Protein Family: | RELT-like protein |
| UniProt Gene Name: | RELT�� |
| UniProt Entry Name: | TR19L_HUMAN |
