null

[KO Validated] STAT3 Rabbit Monoclonal Antibody (CAB19566)

SKU:
CAB19566
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • KO Validated Antibodies 2 Anti-STAT3 Antibody KO Validated CAB19566
  • KO Validated Antibodies 2 Anti-STAT3 Antibody KO Validated CAB19566
  • KO Validated Antibodies 2 Anti-STAT3 Antibody KO Validated CAB19566
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] STAT3 Rabbit Monoclonal Antibody
SKU:CAB19566
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600-700 of human STAT3 (P40763).
Sequence:TKPP GTFL LRFS ESSK EGGV TFTW VEKD ISGK TQIQ SVEP YTKQ QLNN MSFA EIIM GYKI MDAT NILV SPLV YLYP DIPK EEAF GKYC RPES QEHP EADP G
Tested Applications:WB IHC-P IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-600μg extracts of whole cells
Synonyms:APRF; HIES; ADMIO; ADMIO1; T3
Positive Sample:HeLa,A549,NIH/3T3,C6,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:88kDa
Observed MW:86kDa

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.

Purification Method:Affinity purification
Gene ID:6774
Clone Number:ARC2603
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using [KO Validated] STAT3 Rabbit mAb (CAB19566) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

Related Products