The NF-kappaB2 Monoclonal Antibody (CAB22279) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in mice, exhibits high specificity and sensitivity for detecting NF-?B2 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.NF-?B2, also known as p52, is a critical component of the NF-?B signaling pathway that mediates immune and inflammatory responses. Dysregulation of NF-?B2 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
NF-kappaB2 Monoclonal Antibody
SKU:
CAB22279
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC57776
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
4791
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using NF-κB2 Rabbit mAb (CAB22279) at 1:700 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
