Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody (CABP1400)
The Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody (CABP1400) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed for use in Western blot applications, specifically detects the phosphorylated form of cardiac troponin I at serine 23/24 residues.Phosphorylation of cardiac troponin I at these specific sites has been linked to various cardiac conditions, making this antibody essential for studying the molecular mechanisms underlying cardiac disease progression. Its high specificity for the phosphorylated form of troponin I in human samples ensures accurate and reliable results in research related to heart diseases, myocardial infarction, and other cardiovascular disorders.
This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody
SKU:
CABP1400
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC56024
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
RRSS NY
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P
1:500 - 1:1000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF, Phospho-Cardiac Troponin I (TNNI3)-S23/S24
Cellular Localization:
Cardiac Myofibril, Cytosol, Sarcomere.
Calculated MW:
24kDa
Observed MW:
Refertofigures
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
Purification Method
Affinity purification
Gene ID
7137
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Immunohistochemistry analysis of paraffin-embedded Human heart using Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb (CABP1400) at dilution of 1:700 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
