Recombinant Human Annexin A13/ANXA13 Protein (RPES2642)



ELISA Kit Technical Manual

Recombinant Human Annexin A13/ANXA13 Protein

Background:Annexin A13 (ANXA13) belongs to the annexin family which plays a role in phospholipase inhibition, cytoskeletal interactions, intracellular signal transduction pathways and regulation of cellular growth. ANXA13 contains four annexin repeats and a pair of annexin repeats may form one binding site for calcium and phospholipid. ANXA13 is highly expressed in intestinal and kidney epithelial cells. The specific function of ANXA13 has not yet been determined; however it is associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.
Name:Recombinant Human Annexin A13/ANXA13 Protein
Assay Genie SKU:RPES2642
Synonyms:Annexin A13; Annexin XIII; Annexin3; Intestine-Specific Annexin; ISA; ANXA13; ANX13
Expression host:E.coli
Mol Mass:35.4 kDa
AP Mol Mass:33 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 100mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:ANXA13: a calcium/phospholipid-binding protein associated with the cell membrane. ANXA13 is the probable common ancestor of the annexin family of proteins. Annexins all bind to phospholipids in a calcium-dependent manner. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: nucleoplasm; extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft

Molecular Function:calcium-dependent phospholipid binding; phosphatidylserine binding; phosphatidylcholine binding; calcium ion binding

Biological Process: negative regulation of Golgi to plasma membrane protein transport; positive regulation of Golgi to plasma membrane protein transport; cell differentiation

NCBI Summary:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:P27216
NCBI GenInfo Identifier:281185504
NCBI Gene ID:312
NCBI Accession:P27216.3
UniProt Secondary Accession:P27216,Q9BQR5,
UniProt Related Accession:P27216
Molecular Weight:39,744 Da
NCBI Full Name:Annexin A13
NCBI Synonym Full Names:annexin A13
NCBI Official Symbol:ANXA13  
NCBI Official Synonym Symbols:ISA; ANX13  
NCBI Protein Information:annexin A13; annexin3; annexin XIII; intestine-specific annexin; annexin, intestine-specific
UniProt Protein Name:Annexin A13
UniProt Synonym Protein Names:Annexin XIII; Annexin3; Intestine-specific annexin; ISA
Protein Family:Annexin
UniProt Gene Name:ANXA13  
UniProt Entry Name:ANX13_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
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