Human TGFBR2 Recombinant Protein (RPES4049)
- SKU:
- RPES4049
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
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Description
system_update_altDatasheet
Human TGFBR2 Recombinant Protein
TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.
| Product Name: | Human TGFBR2 Recombinant Protein (RPES4049) |
| Product Code: | RPES4049 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | AAT3,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,TAAD2,TGFbeta-RII,TGFR-2,TGF-beta receptor type-2, TGF-beta type II receptor,TGFBR2, Transforming growth factor-beta receptor type II |
| Accession: | P37173 |
| Sequence: | Thr 23-Asp159 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Transforming Growth Factor-beta Receptor Type II is produced by our Mammalian expression system and the target gene encoding Thr23-Asp159 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 42.6 kDa |
| AP Mol Mass: | 59 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
