The SIRT2 Antibody (CAB14109) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbits, exhibits high specificity to human samples and has been validated for use in Western blotting applications. By targeting the SIRT2 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it a versatile tool for investigations in the fields of cell biology and aging research.SIRT2, a NAD-dependent deacetylase enzyme, plays a crucial role in regulating diverse cellular functions, such as gene expression, DNA repair, and cell cycle progression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
SIRT2 Antibody
SKU:
CAB14109
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Purification Method
Affinity purification
Gene ID
22933
RRID
AB_2760964
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using SIRT2 Rabbit pAb (CAB14109) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
