The TRIM28 Polyclonal Antibody (CAB2245) is a valuable tool for researchers studying TRIM28, a protein involved in epigenetic regulation and transcriptional repression. This antibody, generated in rabbits, is highly specific for detecting TRIM28 in human samples and has been validated for use in Western blot applications.TRIM28, also known as KAP1, is a key player in gene regulation and chromatin remodeling processes. Its function in transcriptional silencing and DNA repair makes it a target of interest for studies in cancer research, developmental biology, and epigenetics.
The TRIM28 Polyclonal Antibody binds specifically to TRIM28 protein, enabling researchers to analyze its expression and localization in various cell types.Understanding the role of TRIM28 in gene regulation and epigenetic modifications is essential for unraveling its contribution to disease pathogenesis and identifying potential therapeutic targets. By utilizing the TRIM28 Polyclonal Antibody, researchers can enhance their investigations into the mechanisms underlying TRIM28 function and its implications in various physiological and pathological processes.
Product Name:
KAP1/TRIM28 Rabbit Polyclonal Antibody
SKU:
CAB2245
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 576-835 of human KAP1/KAP1/TRIM28 (NP_005753.1).
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Purification Method:
Affinity purification
Gene ID:
10155
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KAP1/TRIM28 Rabbit pAb (CAB2245) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
