The ATG7 Polyclonal Antibody (CAB7360) is a valuable tool for researchers studying autophagy, a cellular process crucial for maintaining cellular homeostasis and regulating cell survival. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. ATG7, a key protein involved in the autophagy pathway, plays a critical role in the initiation and elongation of autophagosomes, the structures responsible for engulfing and degrading cellular components. Dysregulation of autophagy has been implicated in various diseases such as cancer, neurodegenerative disorders, and metabolic conditions.
By targeting ATG7, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic strategies.The ATG7 Polyclonal Antibody enables precise detection and analysis of ATG7 protein expression in various cell types, making it an invaluable tool for studies in cell biology, cancer research, and drug development. Understanding the role of ATG7 in autophagy offers potential avenues for therapeutic intervention and may lead to the development of novel treatments for a range of human diseases.
Product Name:
ATG7 Rabbit Polyclonal Antibody
SKU:
CAB7360
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-676 of human ATG7 (NP_001129503.2).
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10533
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using ATG7 Rabbit pAb (CAB7360) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
