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For decades, the brain has been considered an immune sanctuary, protected by the formidable blood-brain barrier. This intricate defense system, while vital for safeguarding our most complex organ, has simultaneously posed an immense challenge for delivering therapeutic drugs to treat neurological diseases. But what if there was a hidden "backdoor," a previously overlooked pathway offering a direct route into the brain? Recent groundbreaking research suggests such a gateway exists, nestled within the very bones of our skull. Introduction The concept of the brain as an "immune-privileged" site has long dominated neuroscience, largely due to the blood-brain barrier (BBB) – a highly selective s …