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Haemophilus Influenzae Type B (Hib) Antibodies, Proteins & ELISA Kits

Haemophilus influenzae type b (Hib) Antibodies, Proteins & ELISA Kits | Assay Genie
Infectious Disease · Haemophilus influenzae type b

Haemophilus influenzae type b (Hib) antibodies, proteins & ELISA kits

Haemophilus influenzae type b (Hib) is an encapsulated bacterium that was a leading cause of childhood meningitis and epiglottitis before conjugate vaccines; its polyribosylribitol phosphate (PRP) capsule is the key antigen.

H. influenzae bPRP capsuleVaccine-preventable
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H. influenzae b
Gram-negative
PRP
Capsular polysaccharide
Respiratory
Droplet spread
Hib vaccine
Conjugate
Overview

What is Haemophilus influenzae type b (Hib)?

Haemophilus influenzae type b (Hib) is an encapsulated bacterium that was a leading cause of childhood meningitis and epiglottitis before conjugate vaccines; its polyribosylribitol phosphate (PRP) capsule is the key antigen.

Hib spreads by respiratory droplets. Anti-PRP IgG ELISA is the standard correlate of protection used in Hib vaccine immunogenicity studies.

Transmission & symptoms

Hib spreads by respiratory droplets and, before conjugate vaccination, was a leading cause of childhood bacterial meningitis, epiglottitis and pneumonia. Its polyribosylribitol phosphate (PRP) capsule is the principal virulence factor and protective antigen.

Diagnosis & serology

Protection is measured as anti-PRP (anti-capsular) IgG, the correlate used to license and monitor Hib conjugate vaccines. ELISA quantifies anti-PRP antibody concentrations in immunogenicity and seroprevalence studies.

Research applications

Research tools support Hib vaccine immunogenicity, complement-mediated killing (factor H, C3) and mucosal/systemic antibody responses, plus general markers of invasive bacterial infection.

Products

Haemophilus influenzae type b (Hib) antibodies, proteins & ELISA kits

Validated, in-stock research tools for Haemophilus influenzae type b (Hib) — every link checked and live.

Related research targets

Host receptors, biomarkers and immune targets relevant to Haemophilus influenzae type b (Hib) — antibodies, ELISA kits and In Vivo antibodies from our current catalogue.

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FAQs

Haemophilus influenzae type b (Hib) — frequently asked questions

What is the correlate of protection for Hib?
Anti-PRP (anti-capsular polysaccharide) IgG measured by ELISA; a defined threshold is used to assess Hib conjugate-vaccine responses.
Why was Hib so dangerous in children?
Its polysaccharide capsule resists immune clearance, allowing invasive disease such as meningitis and epiglottitis in young, unimmunised children.
How did conjugate vaccines change Hib disease?
Conjugating PRP to a carrier protein elicits robust T-dependent IgG even in infants, dramatically reducing invasive Hib disease.
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