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Human HMGB1 ELISA Kit

SKU:
HUFI00660
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P09429
Sensitivity:
18.75pg/ml
Range:
31.25-2000pg/ml
ELISA Type:
Sandwich ELISA, Double Antibody
Synonyms:
HMGB1, High mobility group protein B1, HMG-1, HMG1, HMG3, SBP-1, Amphoterin, high mobility group box 1, High mobility group protein 1, high-mobility group, nonhistone chromosomal protein 1, high-mobility group box 1, Sulfoglucuronyl carbohydRate bind
Reactivity:
Human
€449
Frequently bought together:

Description

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Human HMGB1 ELISA Kit

High mobility group protein B1 (HMGB1) is a member of the High Mobility Group-box superfamily. HMGB1 serves as a multifunctional redox sensitive protein with diverse functions in several cellular compartments, including inflammation, cell differentiation, and tumor cell migration. In the nucleus, HMGB1 is one of the main chromatin-associated non-histone proteins and serves as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair, and genome stability. HMGB1 is a sensor and/or chaperone in the cytoplasm that activates TLR9-mediated immune responses and moderates autophagy. HMGB1 has also been shown to act as a danger associated molecular pattern (DAMP) molecule, which enhances the immune response during tissue injury. HMGB1 is believed to play a role in the development of several chronic inflammatory and autoimmune diseases, as well as cancer. High levels of serum HMGB1 have been detected in a number of inflammatory diseases, including sepsis, rheumatoid arthritis, artherosclerosis, chronic kidney disease, and systemic lupus erythematosus (SLE). HMGB1 has also been linked to diabetes and Alzheimer's disease.