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Anti-ANXA3 Antibody (CAB19861)[KO Validated]

SKU:
CAB19861
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
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Description

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Antibody Name:Anti-ANXA3 Antibody [KO Validated]
Antibody SKU:CAB19861
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ANXA3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HeLa
Immunogen:Recombinant protein of human ANXA3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:306
Uniprot:P12429
Cellular Location:
Calculated MW:36kDa
Observed MW:34KDa
Anti-ANXA3 Antibody [KO Validated] (CAB19861)Western blot analysis of extracts from normal (control) and ANXA3 knockout (KO) HeLa cells, using ANXA3 antibody (CAB19861) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:ANXA3, ANX3
Background:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1, 2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
UniProt Protein Function:ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: cytoplasm; membrane; phagocytic vesicle membrane; plasma membrane; specific granule

Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding

Biological Process: defense response to bacterium; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of transcription factor activity

NCBI Summary:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
UniProt Code:P12429
NCBI GenInfo Identifier:113954
NCBI Gene ID:306
NCBI Accession:P12429.3
UniProt Secondary Accession:P12429,Q6LET2, B2R9W6,
UniProt Related Accession:P12429
Molecular Weight:36,375 Da
NCBI Full Name:Annexin A3
NCBI Synonym Full Names:annexin A3
NCBI Official Symbol:ANXA3  
NCBI Official Synonym Symbols:ANX3  
NCBI Protein Information:annexin A3
UniProt Protein Name:Annexin A3
UniProt Synonym Protein Names:35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III
Protein Family:Annexin
UniProt Gene Name:ANXA3  
UniProt Entry Name:ANXA3_HUMAN

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