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Pertussis Antibodies, Proteins & ELISA Kits

Pertussis Antibodies, Proteins & ELISA Kits | Assay Genie
Infectious Disease · Bordetella pertussis

Pertussis antibodies, proteins & ELISA kits

Pertussis (whooping cough) is a respiratory infection caused by Bordetella pertussis, whose pertussis toxin (PT) and filamentous haemagglutinin (FHA) are central virulence factors and vaccine antigens.

B. pertussisPertussis toxin (PT)Whooping cough
B. pertussis
Gram-negative
PT / FHA
Key antigens
Respiratory
Droplet spread
DTaP
Vaccine
Overview

What is Pertussis?

Pertussis (whooping cough) is a respiratory infection caused by Bordetella pertussis, whose pertussis toxin (PT) and filamentous haemagglutinin (FHA) are central virulence factors and vaccine antigens.

It spreads by respiratory droplets and is vaccine-preventable (DTaP/Tdap). Anti-PT IgG ELISA is the standard serological marker for diagnosis and vaccine immunogenicity.

Transmission & symptoms

Bordetella pertussis causes whooping cough, a respiratory infection spread by droplets. Pertussis toxin (PT) and filamentous haemagglutinin (FHA) mediate colonisation and disease, which is characterised by paroxysmal coughing fits and can be severe in infants.

Diagnosis & serology

Anti-PT IgG ELISA is the standard serological marker for recent infection and vaccine response; anti-FHA is also measured. Culture and PCR confirm acute cases.

Research applications

Research tools support pertussis-toxin and FHA immunogenicity, acellular-vaccine responses and the Th1/Th17 and IFN-gamma immunity associated with protection.

FAQs

Pertussis — frequently asked questions

What is the standard serological marker for pertussis?
Anti-pertussis-toxin (anti-PT) IgG by ELISA is the accepted marker for recent infection and vaccine immunogenicity.
Why is pertussis dangerous in infants?
Young infants can develop severe paroxysmal cough, apnoea and complications before vaccination is complete, making maternal and cocoon vaccination important.
What antigens are in acellular pertussis vaccines?
Typically pertussis toxoid and filamentous haemagglutinin (FHA), sometimes with pertactin and fimbriae.

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