Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-βsuperfamily of ligands. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. The mutations of ALK-1 are associated with Rendu-Osler-Weber syndrome 2, this suggests ACVRL1 is associated with blood vessel development and repair.
Product Name:
Human ALK/ACVRL1 Recombinant Protein (RPES4895)
Product Code:
RPES4895
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Serine/Threonine-Protein Kinase Receptor R3, SKR3, Activin Receptor-Like Kinase 1, ALK-1, TGF-B Superfamily Receptor Type I, TSR-I, ACVRL1, ACVRLK1, ALK1,HHT,HHT2,ORW2,SKR3
Accession:
P37023
Sequence:
Asp22-Gln118
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human ALK-1 is produced by our Mammalian expression system and the target gene encoding Asp22-Gln118 is expressed with a Fc tag at the C-terminus.
Purity:
> 90% as determined by reducing SDS-PAGE.
Mol Mass:
37.6 kDa
AP Mol Mass:
50-60 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS,pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
