Anti-OTUD5 Antibody (CAB20516)
- SKU:
- CAB20516
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DUBA
- MCAND
Frequently bought together:
Description
Product Name: | OTUD5 Rabbit pAb |
Product Code: | CAB20516 |
Size: | 50uL, 100uL |
Synonyms: | DUBA, MCAND |
Applications: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 362-571 of human OTUD5 (NP_060072.1). |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 362-571 of human OTUD5 (NP_060072.1). |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 55593 |
Uniprot: | Q96G74 |
Calculated MW: | 60kDa |
Observed MW: | Refer to figures |
UniProt Protein Function: | OTUD5: a protein of unknown function. Contains a OTU-like cysteine protease domain. Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12 Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytosol Molecular Function: ubiquitin-specific protease activity Biological Process: innate immune response; response to lipopolysaccharide; proteolysis; negative regulation of interferon type I production |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q96G74 |
NCBI GenInfo Identifier: | 209977019 |
NCBI Gene ID: | 55593 |
NCBI Accession: | NP_001129629.1 |
UniProt Secondary Accession: | Q96G74,Q4KMN9, Q8N6T5, Q9H650, Q9H9U0, Q9NT65, B4DGG7 G5E9D7 |
UniProt Related Accession: | Q96G74 |
Molecular Weight: | |
NCBI Full Name: | OTU domain-containing protein 5 isoform b |
NCBI Synonym Full Names: | OTU deubiquitinase 5 |
NCBI Official Symbol: | OTUD5Â Â |
NCBI Official Synonym Symbols: | DUBAÂ Â |
NCBI Protein Information: | OTU domain-containing protein 5; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A |
UniProt Protein Name: | OTU domain-containing protein 5 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme A; DUBA |
Protein Family: | |
UniProt Gene Name: | OTUD5Â Â |
UniProt Entry Name: | OTUD5_HUMAN |