The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to; but narrower than; that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family
Product Name:
Human Cathepsin D/CTSD Recombinant Protein (RPES4634)
Product Code:
RPES4634
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Cathepsin D, CTSD,CLN10,CPSD,HEL-S-130P
Accession:
P07339
Sequence:
Leu21-Leu412
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Cathepsin D is produced by our Mammalian expression system and the target gene encoding Leu21-Leu412 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
43.8 kDa
AP Mol Mass:
50 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM MES; 150mM NaCl; pH 5.5.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
