Recombinant Human Cathepsin D/CTSD Protein (His Tag) (RPES4634)

SKU:
RPES4634
€361

Description

ELISA Kit Technical Manual

Recombinant Human Cathepsin D/CTSD Protein (His Tag)

Background:The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to, but narrower than, that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family
Name:Recombinant Human Cathepsin D/CTSD Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES4634
Synonyms:Cathepsin D; CTSD;CLN10;CPSD;HEL-S30P
Species:Human
Expression host:Human Cells
Sequence:Leu21-Leu412
Accession:P07339
Mol Mass:43.8 kDa
AP Mol Mass:50 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.
UniProt Protein Details:

Protein type:Autophagy; Motility/polarity/chemotaxis; Protease; EC 3.4.23.5

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; lysosome; melanosome; extracellular region

Molecular Function:protein binding; aspartic-type endopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10

NCBI Summary:This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
UniProt Code:P07339
NCBI GenInfo Identifier:115717
NCBI Gene ID:1509
NCBI Accession:P07339.1
UniProt Secondary Accession:P07339,Q6IB57,
UniProt Related Accession:P07339
Molecular Weight:44,552 Da
NCBI Full Name:Cathepsin D
NCBI Synonym Full Names:cathepsin D
NCBI Official Symbol:CTSD  
NCBI Official Synonym Symbols:CPSD; CLN10; HEL-S30P  
NCBI Protein Information:cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P
UniProt Protein Name:Cathepsin D
Protein Family:Cathepsin
UniProt Gene Name:CTSD  
UniProt Entry Name:CATD_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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