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Introduction to KIR Blockade in Cancer ImmunotherapyNatural killer (NK) cells are crucial components of the innate immune system, responsible for recognizing and destroying virally infected cells and tumor cells. However, tumors have developed sophisticated mechanisms to evade NK cell-mediated destruction, one of which involves the killer cell immunoglobulin-like receptors (KIRs). These inhibitory receptors allow tumor cells to escape detection by NK cells, leading to tumor persistence and progression.KIR blockade, using monoclonal antibodies like 1-7F9, is an emerging immunotherapy strategy designed to unleash NK cells' full anti-tumor potential. By preventing KIR from binding …