Nectin-2( CD112) is a member of the nectin family, which contains two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. Nectins are type I transmembrane glycoproteins that are calcium-independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs). Nectin2 is widely expressed in human tissues including brain, spinal cord, spleen, kidney, heart and liver. It can form trans-heterodimers with PVRL3/nectin-3 and interacts with CD226. Mutations of alleles of the murine CD112 gene can result in conditions such as morphologically aberrant spermatozoa. It may function in allergic reactions, and accordingly may used as a novel target for anti-allergic therapy.
Product Name:
Mouse CD112/Nectin-2 Recombinant Protein (RPES0264)
Product Code:
RPES0264
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
CD112,nectin2,Herpes virus entry mediator B,Herpesvirus entry mediator B,HveB,Murine herpes virus entry protein B,mHveB,Poliovirus receptor homolog,Poliovirus receptor-related protein 2,Pvrl2,
Accession:
NP_033016.3
Sequence:
Gln32-Gly351
Fusion tag:
C-6His
Activity:
Immobilized Human DNAM-1-Fc(Cat: PKSH033729) at 2µg/ml(100 ?l/well) can bind Human Nectin-2-His.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Gly351 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
35.6 kDa
AP Mol Mass:
40-45 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
