Dendritic Cells

Dendritic Cells

Dendritic cells (DCs) are the most commonly studied antigen presenting cell (APC) in the adaptive immune system. These important cells bridge the gap between innate and adaptive immunity and serve to trigger adaptive immune responses by taking up antigens, migrating, and the presenting those antigens to naive lymphocytes. Dendritic cells are found throughout the body in multiple tissue systems, and uptake extracellular PAMPS for presentation. PAMPS are detected via pattern recognition receptors, which bind certain pathogen motifs.

When a dendritic cell becomes activated, it migrates to the lymph nodes to present its antigen. DCs bear MHC II proteins which allow for antigen presentation. Most nucleated cells express MHC I, but generally only professional antigen presenting cells have MHC II. MHC II can interact with CD4+ helper T cells to activate an adaptive immune response.  

Dendritic Cell Markers

Activation
Immunophenotyping
Chemotaxis & Migration
Differentiation & Development