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Anti-Phospho-ATG13-Ser355 Antibody (CABP1089)

SKU:
CABP1089
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy
€129 - €489
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-ATG13-Ser355 Antibody
Antibody SKU:CABP1089
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho synthetic peptide corresponding to residues surrounding Ser355 of human ATG13.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:C6
Immunogen:A phospho synthetic peptide corresponding to residues surrounding Ser355 of human ATG13.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9776
Uniprot:O75143
Cellular Location:Cytoplasm, Preautophagosomal structure, cytosol
Calculated MW:44kDa/52kDa/56kDa/60kDa
Observed MW:60kDa
Anti-Phospho-ATG13-Ser355 Antibody (CABP1089)Western blot - Phospho-ATG13-Ser355 Rabbit pAb (CABP1089)
Synonyms:KIAA0652, PARATARG8, ATG13
Background:The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
UniProt Protein Function:ATG13: an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle; Autophagy

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: mitochondrion; cytosol

Molecular Function:protein binding; protein kinase binding

Biological Process: autophagic vacuole formation

NCBI Summary:The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
UniProt Code:O75143
NCBI GenInfo Identifier:20140441
NCBI Gene ID:9776
NCBI Accession:O75143.1
UniProt Related Accession:O75143
Molecular Weight:Observed: 57 kDaPredicted: 57 kDa
NCBI Full Name:Autophagy-related protein 13
NCBI Synonym Full Names:autophagy related 13
NCBI Official Symbol:ATG13  
NCBI Official Synonym Symbols:KIAA0652; PARATARG8  
NCBI Protein Information:autophagy-related protein 13
UniProt Protein Name:Autophagy-related protein 13
Protein Family:Autophagy protein
UniProt Gene Name:ATG13  
UniProt Entry Name:ATG13_HUMAN

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