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Anti-Human NRG1-beta1 - Biotin (IVMB0244)

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SKU IVMB0244
Product Type Polyclonal Antibody
Protein NRG1-beta1
Reactivity Human
Synonyms HRG1-beta1
Synonyms HRG
Synonyms Breast Cancer Cell Differentiation Factor p45
Synonyms Acetylcholine Receptor Inducing Activity [ARIA]
Synonyms Glial Factor
Synonyms Neu Differentiation Factor
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Description

system_update_altDatasheet
Product Name:Anti-Human NRG1-β1 - Biotin
Product Code:IVMB0244
Protein:NRG1-?1
Product Type:Polyclonal Antibody
Synonyms:HRG1-?1, HRG, Breast Cancer Cell Differentiation Factor p45, Acetylcholine Receptor Inducing Activity [ARIA], Glial Factor, Neu Differentiation Factor
Reactivity:Human
Immunogen:Purified Recombinant Human NRG1-?1 (Accession # AAA58639)
Applications:ELISA Det, WB
Storage and Handling:The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted bitoin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Host Species:Goat
Specificity:Goat Anti-Human Neuregulin 1-?1 (NRG1-?1) recognizes Human NRG1-?1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances , reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Immunogen:Purified Recombinant Human NRG1-?1 (Accession # AAA58639)
Storage and Handling:The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted bitoin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Neuregulin/Heregulin is a family of related growth factors that are differentially spliced variants of four genes: NRG1, NRG2, NRG3 and NRG4. The longest forms of NRG contains several different modular domains and tissue-specific splicing results in many NRG isoforms containing different sets of these domains. Alternative splicing produces two types of EGF domain, designated a and b. HRG-Beta1 contains an Ig domain and an EGF domain necessary for direct binding to receptor tyrosine kinases erbB-3 and erbB-4. HRG-Beta1 binding causes erbB-3 and erbB-4 to dimerize with erbB-2 (Her2/neu) and thereby regulates the phosphorylation of erbB-2 tyrosines. HRG-Beta1 stimulates proliferation and motility of breast cancer cells and plays a role in wound healing by stimulating epidermal migration and differentiation of epidermal cells and by stimulating the expression of integrins in the epidermis.
Protein:NRG1-?1

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