The BEX2 Antibody (PAC041854) is a valuable tool for researchers studying BEX2, a protein implicated in various cellular processes, including cell growth and differentiation. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the BEX2 protein, allowing for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cancer research and neurobiology.BEX2 is known to play a role in the regulation of cell proliferation and apoptosis, making it a potential target for therapeutic interventions in cancer treatment.
By understanding the function and regulation of BEX2, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and identify potential drug targets for cancer therapy. The BEX2 Antibody is a valuable tool for investigating the role of BEX2 in cancer progression and may lead to the development of novel targeted therapies in the future.
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO41854 at dilution of 1:100.
Immunofluorescence staining of HepG2 cells with PACO41854 at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Synonyms:
Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2), BEX2
